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Rocz Panstw Zakl Hig 1997, 48(2): 111-117

Daminozyd - brak aktywności genotoksycznej w krótkoterminowych testach bakteryjnych
[Daminozide: lack of the genotoxic activity in short-term bacterial test]

I. Rahden-Staroń, H. Czeczot, M. Pieńkowska, T. Szymczyk-Wasiluk

ABSTRACT

In the recent paper genotoxic effects of daminozide and its metabolites were tested. Evaluation of the mutagenic effect of daminozide was by: (i) the Salmonella/mammalian microsome Ames test with S.typhimurium TA97, TA98, TA100 and TA102. (ii) E. coli PQ37 strain to reveal an induction of the SOS response, (iii) S. typhimurium TA1538 (uvrB) and TA1978 (uvr+) to detect the chemicals bound covalently to DNA (repair test). Daminozide was not mutagenic in any of the S.typhimurium strains and did not induce damages in DNA recognized by correndonuclease II, as shown by the repair test. Only metabolites of daminozide induced the SOS system.

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